ADAR1 inhibitor H13

Chemical Structure : ADAR1 inhibitor H13

Catalog No.: PC-27658Not For Human Use, Lab Use Only.

ADAR1 inhibitor H13 is potent, orally bioavailable ADAR1 modulator, exhibits potent antiproliferative activity against various cancer cell lines and selectively reduces ADAR1-mediated editing of APOBEC3D in a dose-dependent manner.

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Biological Activity

ADAR1 inhibitor H13 is potent, orally bioavailable ADAR1 modulator, exhibits potent antiproliferative activity against various cancer cell lines and selectively reduces ADAR1-mediated editing of APOBEC3D in a dose-dependent manner.

Physicochemical Properties

M.Wt	287.68
Formula	C10H11ClFN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-(chloromethyl)tetrahydrofuran-3-ol

References

1. Wei A, et al. J Med Chem. 2026 Aug 13;69(15):18147-18161.

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