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AEBSF

Chemical Structure : AEBSF

CAS No.: 30827-99-7

AEBSF

Catalog No.: PC-43231Not For Human Use, Lab Use Only.

AEBSF is an irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

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100 mg $58 In stock
250 mg $98 In stock
500 mg $158 In stock
1 g $198 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AEBSF is an irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin; inhibits the constitutive production of Aβ by directly inhibiting β-secretase in different human cell lines, both neural and nonneural; inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β; also disturbs the growth of blastocysts on endometrial cells and inhibits the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern; inhibits the rat embryo implantation in vivo.

Physicochemical Properties

M.Wt 239.6948
Formula C8H11ClFNO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1)

References

1. Citron M, et al. Neuron. 1996 Jul;17(1):171-9.

2. Nakabo Y, et al. J Leukoc Biol. 1996 Sep;60(3):328-36.

3. Buitrago-Rey R, et al. J Antimicrob Chemother. 2002 May;49(5):871-4.

4. Jiang YH, et al. Contraception. 2011 Dec;84(6):642-8.

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