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Chemical Structure : AEM2
Catalog No.: PC-62391Not For Human Use, Lab Use Only.
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
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SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
AEM2 sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide.
AEM2 elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.
| M.Wt | 409.533 | |
| Formula | C27H27N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.
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