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Chemical Structure : AF615
Catalog No.: PC-38705Not For Human Use, Lab Use Only.
AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.
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AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.
AF615 inhibits CDT1-Geminin protein-protein interaction, induces DNA damage and blocks DNA synthesis in cancer cells.
AF615 reduces viability selectively in cancer cell lines.
| M.Wt | 267.307 | |
| Formula | C10H13N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Karantzelis N, et al. Front Pharmacol. 2022 Apr 25;13:860682.
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