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Chemical Structure : AG-636
CAS No.: 1623416-31-8
Catalog No.: PC-38194Not For Human Use, Lab Use Only.
AG-636 (AG636) is a novel potent, selective, reversible and oral dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 17 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AG-636 (AG636) is a novel potent, selective, reversible and oral dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 17 nM.
AG-636 exhibited strong growth-inhibitory activity in a distinct subset of cell lines with GI 50 of <1.5 uM.
AG-636 treatment results in robust tumor growth inhibition in xenograft lymphoma tumor models, with comparably poor activity in solid tumor models.
| M.Wt | 343.386 | |
| Formula | C21H17N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-methyl-5-(2'-methyl-[1,1'-biphenyl]-4-yl)-1H-benzo[d][1,2,3]triazole-7-carboxylic acid |
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1. Gabrielle McDonald, et al. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.
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