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Chemical Structure : AG1478
CAS No.: 153436-53-4
Catalog No.: PC-21841Not For Human Use, Lab Use Only.
AG1478 (Tyrphostin AG-1478) is a potent, selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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AG1478 (Tyrphostin AG-1478) is a potent, selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM.
AG1478 inhibits cell growth, DNA synthesis, EGFR tyrosine kinase activity, and receptor autophosphorylation of U87MG cell populations which over-expressed either wt (U87MG.wtEGFR) or truncated EGFR (U87MG. delta EGFR).
AG1478 preferentially inhibits glioblastoma cells with truncated EGFR compared with those with wild-type EGFR.
| M.Wt | 315.76 | |
| Formula | C16H14ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine |
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1. Li W, et al. Sci Rep. 2016 Apr 18;6:24580.
2. Arteaga CL, et al. J Biol Chem. 1997 Sep 12;272(37):23247-54.
3. Han Y, et al. Cancer Res. 1996 Sep 1;56(17):3859-61.
4. Zanella CL, et al. Cancer Res. 1996 Dec 1;56(23):5334-8.
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