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Chemical Structure : AG17724
Catalog No.: PC-49154Not For Human Use, Lab Use Only.
AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in CAFs, leading to efficacious but transient tumor growth inhibition.
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AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in cancer associated fibroblasts (CAFs), leading to efficacious but transient tumor growth inhibition.
| M.Wt | 377.38 | |
| Formula | C21H16FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiaye Liu, et al. Nat Commun. 2022 Jul 25;13(1):4308.
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