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Chemical Structure : AG311
Catalog No.: PC-60649Not For Human Use, Lab Use Only.
A first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization.
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A first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization; induces rapid necrosis in numerous cancer cell lines (IC50=5.9-29.3 uM), also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels; does not increase apoptotic markers such as cleavage of PARP or caspase-3 and -7 activity, retards tumor growth and reduces lung metastases in breast cancer mouse models.
| M.Wt | 321.402 | |
| Formula | C17H15N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bastian A, et al. J Pharmacol Exp Ther. 2015 May;353(2):392-404.
2. Bastian A, et al. Cancer Lett. 2017 Mar 1;388:149-157.
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