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Chemical Structure : AGF347
Catalog No.: PC-72124Not For Human Use, Lab Use Only.
AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM).
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AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM).
AGF347 did not inhibit MTHFD2 at >200 uM.
AGF347 demonstrated in vitro antitumor efficacies in a pancreatic cancer cell line panel (HPAC IC50=194 nM) and BxPC-3 (IC50=80 nM).
AGF347 targeted SHMT2 in the mitochondria, and SHMT1 and the purine biosynthetic enzymes GARFTase and/or AICARFTase in the cytosol.
AGF347 significant in vivo antitumor efficacy with potential for complete responses against both early-stage and upstage MIA PaCa-2 pancreatic tumor xenografts.
| M.Wt | 473.461 | |
| Formula | C22H24FN5O6 | |
| Appearance | Solid | |
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1. Dekhne AS, et al. Mol Pharmacol. 2020 Jan;97(1):9-22.
2. Dekhne AS, et al. Mol Cancer Ther. 2019 Oct;18(10):1787-1799.
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