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Chemical Structure : AGX51
CAS No.: 330834-54-3
Catalog No.: PC-72578Not For Human Use, Lab Use Only.
AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $468 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote |
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AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
AGX51 induces ubiquitin-mediated degradation of Ids, cell growth arrest, and reduced viability.
AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization.
AGX51+aflibercept combination treatment worked better than aflibercept alone.
AGX51 as an anti-neovascular agent is likely due to its effects on blocking cell proliferation and vascular network disruption.
| M.Wt | 429.56 | |
| Formula | C28H31NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide |
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1. Wojnarowicz PM, et al. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
2. Wojnarowicz PM, et al. NPJ Breast Cancer. 2021 May 24;7(1):58.
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