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Chemical Structure : AH237
Catalog No.: PC-72468Not For Human Use, Lab Use Only.
AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively.
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AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively.
AH237 (AH-237) displayed over 50-fold selectivity against a panel of 41 MTases such as PRMTs, PKMTs, NTMT1/2, and DNA methyltransferases (DNMTs), Its potency was also confirmed for PRMT1 (IC50 = 5.9 uM) and PRMT7 (IC50 = 831 nM).
| M.Wt | 695.805 | |
| Formula | C26H45N15O6S | |
| Appearance | Solid | |
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1. Ayad A Al-Hamashi, et al. Acta Pharm Sin B. 2021 Sep;11(9):2709-2718.
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