Cat. No. |
Product Name |
Information |
PC-21348 |
Salvianolic acid C
YTHDF1 inhibitor
|
Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1. |
PC-21346 |
MS1262
G9a/GLP inhibitor
|
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively. |
PC-21038 |
KTX-1001
NSD2 inhibitor
|
KTX-1001 is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain. |
PC-49859 |
DS-1594a
Menin-MLL1 inhibitor
|
DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c. |
PC-49813 |
EM127
SMYD3 inhibitor
|
EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase. |
PC-49724 |
JS1310
PRMT7 inhibitor
|
JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM). |
PC-49679 |
METTL3 inhibitor UZH2
METTL3 inhibitor
|
METTL3 inhibitor UZH2 is a potent, selective and cell-permeable RNA methyltransferase METTL3 inhibitor with IC50 of 5 nM in TR-FRET assays. |
PC-49559 |
PRT382
PRMT5 inhibitor
|
PRT382 (PRT-382) is a potent, selective and SAM-competitive PRMT5 inhibitor with IC50 of 2.8 nM in filtration binding assays with recombinant human PRMT5/MEP50 and histone H2A as the protein substrate. |
PC-49558 |
CWI1-2
IGF2BP2 inhibitor
|
CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo. |
PC-49393 |
EPIC-0412
HOTAIR-EZH2 inhibitor
|
EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis. |
PC-49209 |
UNC6934
NSD2-PWWP1 inhibitor
|
UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes. |
PC-49020 |
TC-E 5003
PRMT1 inhibitor
|
TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9. |