| Cat. No. |
Product Name |
Information |
| PC-25345 |
SKLB-Y13
YTHDF1 inhibitor
|
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins. |
| PC-25321 |
IACS-17596
NSD2 inhibitor
|
IACS-17596 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 8.8 nM, >300-fold selective over a KMT panel including NSD1, NSD3 and SETD2. |
| PC-24610 |
AM-9934
PRMT5 inhibitor
|
AM-9934 is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of12 nM for PRMT5 methyltransferase activity and 40 nM for PRMT5:MEP50 enzymatic affinity, selectively inhibits PRMT5 in MTAP-deleted cells. |
| PC-24609 |
BCOR-PCGF1 inhibitor iBP
PRC1.1 inhibitor
|
BCOR-PCGF1 inhibitor iBP is a selective PRC1.1 inhibitor, specifically inhibits the interaction between BCOR and PCGF1 with IC50 of 12.21 uM in AlphaScreen assays, limits H2AK119ub1 activity and activates Wnt signaling pathway. |
| PC-24531 |
CG3-46
CBX2 inhibitor
|
CG3-46 is a specific nonpeptide small molecule CBX2 inhibitor, inhibits the interaction between CBX2 and H3K27me3 with IC50 of 15.4 μM and 14.6 μM in NanoBRET and NanoBiT assays, respectively. |
| PC-24327 |
NSD3 inhibitor A8
NSD3 inhibitor
|
NSD3 inhibitor A8 is a potent small molecule inhibitor of nuclear receptor-binding SET domain protein 3 (NSD3) with IC50 of 0.7 uM, inhibits NSD1 and NSD2 with IC50 of 1.5 uM and 0.9 uM respectively. |
| PC-24232 |
Nsun2-i4
NSUN2 inhibitor
|
Nsun2-i4 is a specific small molecule inhibitor of m5C methyltransferase NSUN2 with KD of 2.65 uM in MST assays. |
| PC-24016 |
EP652
METTL3 inhibitor
|
EP652 is a potent, selective and in vivo active inhibitor of RNA methyltransferase METTL3 with IC50 of 2 nM (METTL3/14) in SPA primary assays. |
| PC-23812 |
DS79932728
G9a/GLP inhibitor
|
DS79932728 is a potent and orally bioavailable histone lysine methyltransferase EHMT2/1 (G9a/GLP) inhibitor with IC50 of 12.6/75.7 nM respectively. |
| PC-23618 |
AS-254s
ASH1L inhibitor
|
AS-254s is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
| PC-23070 |
ZYZ384
SMYD3 inhibitor
|
ZYZ384 (ZYZ-384) is a small molecule inhibitor of histone lysine methyltransferase SMYD3 with KD value of 78 uM, reduces cell proliferation against human hepatoma HepG2 cells with IC50 of 5.23 uM. |
