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Chemical Structure : AJ2-30
CAS No.: 2700322-79-6
Catalog No.: PC-21683Not For Human Use, Lab Use Only.
AJ2-30 is a specific small molecule SLC15A4 inhibitor with IFN-α suppression IC50 of 1.8 µM and MDP transport inhibition IC50 of 2.6 µM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $688 | In stock | |
| 100 mg | Get quote |
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AJ2-30 is a specific small molecule SLC15A4 inhibitor with IFN-α suppression IC50 of 1.8 µM and MDP transport inhibition IC50 of 2.6 µM.
AJ2-30 shows no activity against a related family member, SLC15A3.
AJ2-30 displays similar activity against murine Slc15a4-mediated NOD2 activation.
AJ2-30 also blocks R848-induced activation of TLR7/8 signaling as well as TriDAP-induced and MDP-induced activation of NOD1 and NOD2 signaling, respectively, in THP-1 reporter cells.
AJ2-30 (10 uM) inhibites TLR7/8-induced production of TNF-α in human monocytes, also suppresses MDP-mediated and TriDAP-mediated TNF-α production in human macrophages, displays cross-species reactivity, suppressing IFN-α production in mouse pDCs.
AJ2-30 suppresses TLR7-9 and NOD activation of mouse immune cells in an Slc15a4-dependent manner.
AJ2-30 induces lysosomal-mediated degradation of SLC15A4.
AJ2-30 reduces inflammation in lupus patient cells and mice, suppresses inflammatory cytokine production in lupus patient-derived PBMCs.
| M.Wt | 354.46 | |
| Formula | C23H22N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((9-ethyl-9H-carbazol-3-yl)methyl)-1-methyl-1H-benzo[d]imidazol-2-amine |
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1. Tzu-Yuan Chiu, et al. Nat Chem Biol. 2024 Jan 8. doi: 10.1038/s41589-023-01527-8.
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