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Chemical Structure : AKI-603
CAS No.: 1432515-73-5
Catalog No.: PC-61353Not For Human Use, Lab Use Only.
A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $188 | In stock | |
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AKI-603 (AKI 603) is a small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent.
AKI-603 disrupts normal spindle structure, and induces cell-cycle arrest.
AKI-603 suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4).
AKI-603 reduces xenograft tumor growth after intragastric administration.
| M.Wt | 409.454 | |
| Formula | C19H23N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N4-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-N2-(4-nitrophenyl)pyrimidine-2,4-diamine |
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1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003.
2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96.
3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533.
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