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AKR-XI-85

Chemical Structure : AKR-XI-85

CAS No.: 2382851-72-9

AKR-XI-85

Catalog No.: PC-28491Not For Human Use, Lab Use Only.

AKR-XI-85 is a potent, non-retinoid triazolopyrimidine Retinol-Binding Protein 4 (RBP4) antagonist with binding IC50 of 23 nM in SPA assay and 194 nM in TTR-RBP4 HTRF assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AKR-XI-85 is a potent, non-retinoid triazolopyrimidine Retinol-Binding Protein 4 (RBP4) antagonist with binding IC50 of 23 nM in SPA assay and 194 nM in TTR-RBP4 HTRF assay.

Physicochemical Properties

M.Wt 401.39
Formula C20H18F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methanone, [(3aR,6aS)-hexahydro-5-[2-(trifluoromethyl)phenyl]cyclopenta[c]pyrrol-2(1H)-yl][1,2,4]triazolo[1,5-a]pyrimidin-2-yl-, rel-

References

1. Rinderspacher KA, et al. bioRxiv [Preprint]. 2026 Sep 21:2026.09.14.751502.

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