Catalog No.: PC-27112Not For Human Use, Lab Use Only.
AL-34662 is a potent, selective, and efficacious serotonin-2 (5-HT2) receptor agonist with binding IC50 of 0.8-1.5 nM for rat and human 5-HT2 receptors, and 3-14.5 nM for cloned human 5-HT2A-C receptors.
AL-34662 is a potent, selective, and efficacious serotonin-2 (5-HT2) receptor agonist with binding IC50 of 0.8-1.5 nM for rat and human 5-HT2 receptors, and 3-14.5 nM for cloned human 5-HT2A-C receptors. AL-34662 stimulated phosphoinositide turnover in human ciliary muscle (h-CM; EC50=289+/-80 nM) and in human trabecular meshwork (h-TM; EC50=254+/-50 nM) cells. AL-34662 also mobilized intracellular Ca2+ ([Ca2+]i) in h-CM (EC50=140+/-23 nM) and h-TM (EC50=38+/-8 nM) cells. AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes, efficaciously lowered intraocular pressure (IOP) in the conscious ocular hypertensive monkey eyes.
