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Chemical Structure : ALLO-1
Catalog No.: PC-62177Not For Human Use, Lab Use Only.
ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM).
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ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM); binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.
| M.Wt | 314.769 | |
| Formula | C17H15ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tao H, et al. Chem Biol. 2011 Apr 22;18(4):432-7.
2. Sharpe HJ, et al. Nat Chem Biol. 2015 Apr;11(4):246-55.
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