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ALOX15-IN-1

Chemical Structure : ALOX15-IN-1

CAS No.: 2764818-24-6

ALOX15-IN-1

Catalog No.: PC-27388Not For Human Use, Lab Use Only.

ALOX15-IN-1 (Compound 8b) is a potent, substrate-selective and allosteric inhibitor of mammalian Arachidonic acid 15-lipoxygenase (ALOX15) orthologs, inhibits linoleate oxygenase activity of rabbit and human ALOX15 with IC50 of 0.04 uM, without affecting arachidonic acid oxygenation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALOX15-IN-1 (Compound 8b) is a potent, substrate-selective and allosteric inhibitor of mammalian Arachidonic acid 15-lipoxygenase (ALOX15) orthologs, inhibits linoleate oxygenase activity of rabbit and human ALOX15 with IC50 of 0.04 uM, without affecting arachidonic acid oxygenation.

Physicochemical Properties

M.Wt 473.59
Formula C24H31N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

octyl (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate

References

1. Alexey Golovanov, et al. J Med Chem. 2022 Feb 10;65(3):1979-1995.

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