Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ALRN-6924
CAS No.: 1451199-98-6
Catalog No.: PC-72829Not For Human Use, Lab Use Only.
ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDMX.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $288 | In stock | |
| 5 mg | $498 | In stock | |
| 10 mg | $798 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDMX.
ALRN-6924 demonstrated potent anti-proliferative activity in a dose-dependent manner in two ER+ cell lines with WT TP53, MCF-7 and ZR-75-1, with IC50 values of 113 nM and 500 nM respectively.
The combination of ALRN-6924 and chemotherapeutic agents synergistically inhibit cell proliferation in vitro, ALRN-6924 combined with paclitaxel reactivates p53 and induces cell cycle arrest and apoptosis in vitro.
ALRN-6924 mutually enhances both paclitaxel and eribulin antitumor efficacy and inhibits tumor growth in vivo.
| M.Wt | 1930.28 | |
| Formula | C95H140N20O23 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
42,112-(7E)-7-Undecene-1,11-diyl-N-acetyl-L-leucyl-L-threonyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-leucyl-D-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-D-alaninamide |
|
1. Pairawan S, et al. Breast Cancer Res. 2021 Mar 4;23(1):29.
2. Liao G, et al. Eur J Med Chem. 2018 Nov 5;159:1-9.
3. Saleh MN, et al. Clin Cancer Res. 2021 Jul 22:clincanres.0715.2021.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
