| Cat. No. |
Product Name |
Information |
| PC-49217 |
UCI-LC0019
mutant p53 reactivator
|
UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49216 |
UCI-LC0023
mutant p53 reactivator
|
UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49198 |
Morncide
p53-Morn3 inhibitor
|
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells. |
| PC-49087 |
BAY 249716
p53 modulator
|
BAY 249716 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C. |
| PC-49086 |
BAY 1892005
p53 modulator
|
BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values. |
| PC-72829 |
ALRN-6924
MDM2/MDMX inhibitor
|
ALRN-6924 (ALRN6924) is a potent dual inhibitor of MDM2/MDMX. |
| PC-72590 |
ReACp53
p53 mutants rescuer
|
ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines. |
| PC-72589 |
ADH-6
p53 mutants rescuer
|
ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W). |
| PC-38124 |
NSC194598
|
NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo. |
| PC-38075 |
H210
Mdm2/MdmX inhibitor
|
H210 is a potent dual Mdm2/MdmX inhibitor with Ki of 9.66/2.89 nM, respectively.. |
| PC-38074 |
H203
Mdm2/MdmX inhibitor
|
H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively. |
| PC-42959 |
AMG 232
|
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM. |
