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Chemical Structure : ALX-5407 hydrochloride
Catalog No.: PC-62960Not For Human Use, Lab Use Only.
ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
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ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM; has little or no activity at the GlyT2 transporter, at other binding sites for glycine, or at other neurotransmitter transporters; increases free glycine levels in rat prefrontal cortex (10 mg/kg, p.o.).
Schizophrenia
Discontinued
| M.Wt | 429.916 | |
| Formula | C24H25ClFNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Atkinson BN, et al. Mol Pharmacol. 2001 Dec;60(6):1414-20.
2. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.
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