| Cat. No. |
Product Name |
Information |
| PC-61461 |
ALX 5407
|
ALX 5407 ((+)-NFPS) is a potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS. |
| PC-61460 |
NFPS
|
NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2. |
| PC-60676 |
GSK 494581A
GlyT1 inhibitor
|
GSK 494581A is a potent, specific and mixed glycine transporter subtype 1 (GlyT1) inhibitor (pIC50=7.7) and GPR55 agonist (pEC50=6.5). |
| PC-60526 |
Opiranserin
|
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM). |
| PC-60446 |
ALX-1393
GlyT2 inhibitor
|
ALX-1393 (ALX 1393, ALX1393) is a potent, specific GlyT2 inhibitor with Ki of <1 uM. |
| PC-60445 |
Org 25543
GlyT2 inhibitor
|
Org 25543 is a potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1. |
| PC-42706 |
Bitopertin
GlyT1 inhibitor, Nrf2 activator
|
Bitopertin (RG1678, RO4917838) is a potent and selective glycine uptake GlyT1 inhibitor with EC50 of 30 nM, also is an Nrf2 activator. |
| PC-38397 |
Iclepertin
GlyT1 inhibitor
|
Iclepertin (BI 425809) is a potent, selective and oral glycine transporter 1 (GlyT1) inhibitor with IC50 of 5.2 nM in rat primary neurons and 5.0 nM in human SK‐N‐MC cells (3H‐glycine uptake). |
| PC-35393 |
GlyT1 inhibitor 46
|
GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively. |
| PC-62960 |
ALX-5407 hydrochloride
|
ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM. |
| PC-61835 |
PF-03463275
|
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM. |
| PC-61459 |
TASP0315003
|
A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM). |
