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ALX 5407

Chemical Structure : ALX 5407

CAS No.: 571147-18-7

ALX 5407 ((+)-NFPS)

Catalog No.: PC-61461Not For Human Use, Lab Use Only.

ALX 5407 ((+)-NFPS) is a potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ALX 5407 ((+)-NFPS) is a is a potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS.
ALX 5407 ((+)-NFPS) is a induces a pattern of c-Fos immunoreactivity comparable with the atypical antipsychotic clozapine and enhanced prepulse inhibition of the acoustic startle response in mice.

Physicochemical Properties

M.Wt 393.45
Formula C24H24FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)-N-methylglycine

References

1. Kinney GG, et al. J Neurosci. 2003 Aug 20;23(20):7586-91.

2. Huang B, et al. Cell Physiol Biochem. 2016;38(5):1952-62.

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