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Chemical Structure : AM-6761
Catalog No.: PC-60440Not For Human Use, Lab Use Only.
AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.
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AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.
AM-6761 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 11 mg/kg.
| M.Wt | 695.686 | |
| Formula | C33H37Cl2FN2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88.
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