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Chemical Structure : AM-8553
Catalog No.: PC-60441Not For Human Use, Lab Use Only.
AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.
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AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.
AM-8553 exhibits excellent pharmacokinetic properties and in vivo efficacy.
| M.Wt | 478.41 | |
| Formula | C25H29Cl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rew Y, et al. J Med Chem. 2012 Jun 14;55(11):4936-54.
2. Bernard D, et al. J Med Chem. 2012 Jun 14;55(11):4934-5.
3. Lucas BS, et al. J Am Chem Soc. 2012 Aug 1;134(30):12855-60.
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