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Chemical Structure : AM-8735
Catalog No.: PC-60442Not For Human Use, Lab Use Only.
AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.
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AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.
AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 41 mg/kg.
| M.Wt | 568.506 | |
| Formula | C27H31Cl2NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gonzalez AZ, et al. J Med Chem. 2014 Mar 27;57(6):2472-88.
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