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Chemical Structure : AMG-9810
CAS No.: 545395-94-6
Catalog No.: PC-42419Not For Human Use, Lab Use Only.
AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively.
AMG-9810 blocks capsaicin-evoked depolarization and CGRP release in cultures of rat dorsal root ganglion primary neurons.
AMG-9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.
| M.Wt | 337.42 | |
| Formula | C21H23NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)- |
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1. Gavva NR, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84.
2. Gavva NR, et al. J Neurosci. 2007 Mar 28;27(13):3366-74.
3. Peles S, et al. Neuroscience. 2009 Jun 30;161(2):515-25.
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