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Chemical Structure : AMG PERK 44
Catalog No.: PC-49287Not For Human Use, Lab Use Only.
AMG PERK 44 (AMG44) is a potent, highly selective, and orally active protein kinase RNA-like ER kinase (PERK) inhibitor with IC50 of 6 nM, inhibits cellular PERK autophosphorylation (pPERK) with IC50 of 84 nM.
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AMG PERK 44 (AMG44) is a potent, highly selective, and orally active protein kinase RNA-like ER kinase (PERK) inhibitor with IC50 of 6 nM, inhibits cellular PERK autophosphorylation (pPERK) with IC50 of 84 nM.
AMG PERK 44 (AMG44) displays 1000-fold selectivity over GCN2, exquisite selectivity over a large panel of kinases.
AMG PERK 44 (AMG44) robustly inhibits PERK autophosphorylation (ED50=3 mg/kg; ED90=60 mg/kg) in a time course pharmacodynamic (PD) model assay.
| M.Wt | 524.624 | |
| Formula | C34H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roest G, et al. Cells. 2018 Nov 30;7(12):239.
2. Diego Rojas-Rivera, et al. Cell Death Differ. 2017 Jun;24(6):1100-1110.
3. Smith AL,et al. J Med Chem 2015; 58: 1426–1441.
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