Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AMP945
CAS No.: 1393653-34-3
Catalog No.: PC-20058Not For Human Use, Lab Use Only.
Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | $1480 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.
AMP945 is highly selective for FAK across 468 kinase screening.
AMP945 shows potential for the treatment of pancreatic cancer in combination with standard of care gemcitabine and nab-paclitaxel.
| M.Wt | 527.59 | |
| Formula | C28H32F3N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-[2-[2-[[2-Methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]ethyl]benzeneacetamide |
|
1. John Lambert, et al. Cancer Res (2022) 82 (22_Supplement): A015.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
