| Cat. No. |
Product Name |
Information |
| PC-73097 |
ZINC40099027
FAK activator
|
ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM. |
| PC-36068 |
BI-4464
FAK inhibitor
|
BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM.. |
| PC-35210 |
FAK inhibitor 5
|
FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM. |
| PC-43388 |
NVP-TAE226
FAK inhibitor
|
NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases. |
| PC-42951 |
Defactinib
FAK inhibitor
|
Defactinib (VS-6063, PF-04554878) is a potent, selective and orally active FAK inhibitor, selectively inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines. |
| PC-62802 |
PF-719 dihydrochloride
Pyk2 inhibitor
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM). |
| PC-62800 |
PF-431396
FAK/Pyk2 inhibitor
|
PF-431396 is a highly potent, dual PYK2/FAK inhibitor with IC50 of 11 and 2 nM, respectively, promotes osteogenesis of hMSC cultures. |
| PC-61370 |
Conteltinib
|
CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo. |
| PC-60275 |
BI-853520
PTK2/FAK inhibitor
|
Ifebemtinib (BI 853520) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays. |
| PC-42177 |
GSK-2256098
|
GSK-2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM. |
| PC-42601 |
PF-562271
FAK/Pyk2 inhibitor
|
PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively. |
| PC-42600 |
PF-562271 besylate
FAK/Pyk2 inhibitor
|
A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively. |
