| Cat. No. |
Product Name |
Information |
| PC-22945 |
M64HCl
FAK activator
|
M64HCl is a specific small molecule, water-soluble focal adhesion kinase (FAK) activator, interacts directly with the FAK kinase domain to activate FAK, induces epithelial sheet migration in vitro, and stimulates gut mucosal wound healing in vivo. |
| PC-20683 |
BSJ-04-175
FAK inhibitor
|
BSJ-04-175 is a potent, selective focal adhesion kinase (FAK, protein tyrosine kinase 2 or PTK2) inhibitor with biochemical IC50 of 22 nM, 30-fold selectivity over PYK2. |
| PC-20058 |
AMP945
FAK inhibitor
|
Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2. |
| PC-73097 |
ZINC40099027
FAK activator
|
ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM. |
| PC-72153 |
BJG-03-025
FAK inhibitor
|
BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM. |
| PC-36068 |
BI-4464
FAK inhibitor
|
BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM.. |
| PC-35210 |
FAK inhibitor 5
FAK inhibitor
|
FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM. |
| PC-43388 |
NVP-TAE226
FAK/Pyk2 inhibitor
|
NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases. |
| PC-43036 |
Y15
FAK inhibitor
|
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK. |
| PC-42952 |
Defactinib hydrochloride
FAK inhibitor
|
Defactinib (VS-6063,PF-04554878) is a potent, selective and orally active FAK inhibitor, inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines. |
| PC-42951 |
Defactinib
FAK inhibitor
|
Defactinib (VS-6063, PF-04554878) is a potent, selective and orally active FAK inhibitor, selectively inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines. |
| PC-62802 |
PF-719 dihydrochloride
Pyk2 inhibitor
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM). |
