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Chemical Structure : AMXT-1501 tetrahydrochloride
Catalog No.: PC-36048Not For Human Use, Lab Use Only.
AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO.
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AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO; completely blocked radiolabeled spermidine uptake in multiple NB cell lines, whereas the combination of AMXT 1501 and DFMO was synergistic in reducing colony formation in BE(2)-C and KELLY cells; The combination treatment resulted in hypophosphorylation of retinoblastoma protein (Rb), suggesting growth inhibition via G1 cell cycle arrest in NB cells; inhibits polyamine synthesis and uptake, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.
Solid Tumors
Phase 1 Clinical
| M.Wt | 714.768 | |
| Formula | C32H72Cl4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.
2. Samal K, et al. Int J Cancer. 2013 Sep 15;133(6):1323-33.
3. Hayes CS, et al. Cancer Immunol Res. 2014 Mar;2(3):274-85.
4. Murray-Stewart TR, et al. Biochem J. 2016 Oct 1;473(19):2937-53.
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