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Chemical Structure : AMZ30
Catalog No.: PC-43242Not For Human Use, Lab Use Only.
AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs.
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AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs; selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells (IC50=3.5 uM in HEK 293T cells); AMZ30 is a valuable pharmacological probe to study the role of methylation in regulating PP2A function.
| M.Wt | 461.4435 | |
| Formula | C19H12FN3O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bachovchin DA, et al. J Med Chem. 2011 Jul 28;54(14):5229-36.
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