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Chemical Structure : ANA-12
CAS No.: 219766-25-3
Catalog No.: PC-43064Not For Human Use, Lab Use Only.
ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $568 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.
ANA-12 decreases TrkB activity in the brain without affecting neuronal survival, anxiolytic and antidepressant activity in mice.
| M.Wt | 407.4854 | |
| Formula | C22H21N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]- |
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1. Cazorla M, et al. J Clin Invest. 2011 May;121(5):1846-57.
2. Walsh JJ, et al. Nat Neurosci. 2014 Jan;17(1):27-9.
3. Chen W, et al. Eur J Neurosci. 2014 May;39(9):1439-54.
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