| Cat. No. |
Product Name |
Information |
| PC-49205 |
GNF-5837
pan-TRK inhibitor
|
GNF-5837 (GNF5837) is a potent, selective, and orally bioavailable pan-TRK inhibitor with IC50 values of 11/9/7 nM against TRKA/B/C, respectively. |
| PC-49116 |
Anizatrectinib
TrkA inhibitor
|
Anizatrectinib is a potent and orally active inhibitor of TrkA kinase with potential for inflammatory disease such as prostatitis. |
| PC-43265 |
LOXO-101
Trk inhibitor
|
LOXO-101 (ARRY-470, Larotrectinib) is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. |
| PC-63210 |
AZ-23
|
AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively. |
| PC-43064 |
ANA-12
TrkB inhibitor
|
ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions. |
| PC-61912 |
Ro 08-2750
|
Ro 08-2750 (Ro 082750) is a potent, selective, non-peptide nerve growth factor (NGF) inhibitor that binds to NGF dimer with Kd of 1 uM. |
| PC-61680 |
LM22A-4
TrkB agonist
|
LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR). |
| PC-60903 |
LOXO-195 R racemate
Trk inhibitor
|
The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.. |
| PC-60901 |
LOXO-195
Trk inhibitor
|
LOXO-195 (Selitrectinib;LOXO 195, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively. |
| PC-70173 |
Lestaurtinib
JAK2/FLT3 inhibitor
|
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively. |
| PC-70171 |
K252a
TrkB inhibitor
|
K252a (SF2370) is a potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases. |
| PC-21241 |
PTX-BD10-2
TrkB/C agonist
|
PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity. |
