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Chemical Structure : AP736
Catalog No.: PC-21492Not For Human Use, Lab Use Only.
AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.
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AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.
AP736 inhibits key melanogenic enzymes and the suppression of PKA-CREB signaling pathway.
AP736 markedly inhibits intracellular tyrosinase activity in the α-MSH-stimulated B16F10 melanoma cells.
AP736 does not directly inhibit tyrosinase activity.
AP736 induces GSK3β phosphorylation and reduces the MITF protein level.
| M.Wt | 437.54 | |
| Formula | C26H31NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee CS, et al. Exp Dermatol. 2013 Nov;22(11):762-4.
2. Shin HJ, et al. Int J Mol Med. 2015 Nov;36(5):1353-60.
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