Chemical Structure : APE1 inhibitor C10
CAS No.:
1227098-30-7
APE1 inhibitor C10
(Refi-10)
Catalog No.: PC-26426Not For Human Use, Lab Use Only.
APE1 inhibitor C10 (Refi-10) is a specific small molecule inhibitor of redox activity of APE1 with binding affinity (SPR Kd) of 189 nM, inhibits the redox function, but not the DNA repair function of APE1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
APE1 inhibitor C10 (Refi-10) is a specific small molecule inhibitor of redox activity of APE1 with binding affinity (SPR Kd) of 189 nM, inhibits the redox function, but not the DNA repair function of APE1.
C10 blocks AP-1 DNA binding activity with IC50 of 17 uM in EMSA assays.
C10 inhibits KSHV lytic replication through blocking AP-1 signaling and RTA expression, inhibits intracellular DNA and extracellular virion with IC50 and EC50 of 4.6 uM and 0.16 uM respectively.
C10 (10 uM) inhibits KSHV-induced angiogenesis of oral mesenchymal stem cells (MSCs), inhibits KSHV-mediated secretion of angiogenic growth factors VEGF-A, IL-6 and IL-8 from PDLSCs.
Physicochemical Properties
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M.Wt
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284.31
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Formula
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C17H16O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1E,6E)-1,7-bis(5-methylfuran-2-yl)hepta-1,6-diene-3,5-dione
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References
1. Canrong Zhong, et al. PLoS Pathog. 2017 Apr 5;13(4):e1006289.
2. Yan C, et al. Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):47.
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