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Chemical Structure : AQ-101
Catalog No.: PC-63188Not For Human Use, Lab Use Only.
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.
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AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.
AQ-101 induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo.
AQ-101 inhibits development of ALL in nude or SCID mice with a human ALL xenograft.
| M.Wt | 331.708 | |
| Formula | C16H10ClNO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507.
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