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Chemical Structure : AQX-435
Catalog No.: PC-72440Not For Human Use, Lab Use Only.
AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
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AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
AQX-435 co-operated with the BTK inhibitor ibrutinib to enhance inhibition of anti-IgM-induced AKT phosphorylation.
AQX-435 induced caspase-dependent apoptosis of CLL cells preferentially as compared to normal B cells.
AQX-435 induced TMD8 cell apoptosis in vitro with an IC50 of 2 uM, and overcame in vitro survival promoting effects of microenvironmental stimuli.
AQX-435 reduced AKT phosphorylation and growth of DLBCL in vivo, and co-operated with ibrutinib for tumor growth inhibition.
| M.Wt | 450.579 | |
| Formula | C27H34N2O4 | |
| Appearance | Solid | |
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1. Elizabeth A Lemm, et al. Clin Cancer Res. 2020 Apr 1;26(7):1700-1711.
2. Packham G, et al. Cancer Research. 2018;78(13).
3. Packham G, et al. Blood. 2016;128(22):2037.
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