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Chemical Structure : AR-C155858
CAS No.: 496791-37-8
Catalog No.: PC-43427Not For Human Use, Lab Use Only.
AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $428 | In stock | |
| 50 mg | $1180 | In stock | |
| 100 mg | Get quote |
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AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4; inhibits glycolysis and glutathione synthesis, inhibits tumor cell proliferation; suppresses lactate export, glycolysis, and tumor growth by blocking MCT1/2 in Ras-transformed fibroblasts.
| M.Wt | 461.5346 | |
| Formula | C21H27N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)- |
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1. Ovens MJ, et al. Biochem J. 2010 Jan 15;425(3):523-30.
2. Ovens MJ, et al. Biochem J. 2010 Oct 15;431(2):217-25.
3. Le Floch R, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8.
4. Doherty JR, et al. Cancer Res. 2014 Feb 1;74(3):908-20.
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