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Chemical Structure : AR420626
CAS No.: 1798310-55-0
Catalog No.: PC-49032Not For Human Use, Lab Use Only.
AR420626 is a potent, selective GPR41/FFA3 agonist with pEC50 of 5.74 in [35S]GTPγS-binding assays, induces apoptosis in HCC cells, including HepG2 and HLE cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AR420626 is a potent, selective GPR41/FFA3 agonist with pEC50 of 5.74 in [35S]GTPγS-binding assays, induces apoptosis in HCC cells, including HepG2 and HLE cells.
AR420626 elicits an extrinsic apoptotic pathway and histone deacetylase inhibition, and inhibits growth of HepG2 xenografts.
AR420626 induces apoptosis via the TNF-α-induced extrinsic apoptotic pathway.AR420626 induces apoptosis via activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway in HepG2 cells.
| M.Wt | 417.286 | |
| Formula | C21H18Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxamide |
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1. Mikami D, et al. Ther Adv Med Oncol. 2020 Mar 20;12:1758835920913432.
2. Said H, et al. Dig Dis Sci. 2017 Aug;62(8):1944-1952.
3. Brian D Hudson, et al. Mol Pharmacol. 2014 Aug;86(2):200-10.
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