| Cat. No. |
Product Name |
Information |
| PC-21247 |
AH7614
GPR120 (FFAR4) inhibitor
|
AH-7614 is a potent and selective FFA4 (GPR120) antagonist with pIC50 of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. |
| PC-20767 |
TUG-2304
FFA2 (GPR43) antagonist
|
TUG-2304 (TUG2304) is a highly potent FFA2 (GPR43) antagonist with IC50 of 3-4 nM in both cAMP and GTPγS assays. |
| PC-49032 |
AR420626
GPR41 agonist
|
AR420626 is a potent, selective GPR41/FFA3 agonist with pEC50 of 5.74 in [35S]GTPγS-binding assays, induces apoptosis in HCC cells, including HepG2 and HLE cells. |
| PC-72422 |
CFMB
FFAR2 (GPR43) agonist
|
CFMB (FFA2R agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist/modulator. |
| PC-72119 |
CPL207280
GPR40 agonist
|
CPL207280 (CPL 207280) is a novel potent, selective GPR40/FFA1 agonist with EC50 of 80 nM in a Ca2+ influx assay, shows greater potency than fasiglifam (EC50=270 nM). |
| PC-38228 |
MK-8666
GPR40 agonist
|
MK-8666 is a potent, selective partial GPR40 agonist with EC50 of 0.9 nM, shows potential for the treatment of type 2 diabetes mellitus. |
| PC-35696 |
(S)-4CMTB
FFA2 agonist
|
(S)-4CMTB (AMG 7703, Phenylacetamide 1) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.7 and 0.96 uM for hFFA2 and mFFA2, respectively. |
| PC-35695 |
TUG-1375
FFA2 agonist
|
TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11. |
| PC-35510 |
GPR40 AgoPAM AP5
GPR40 agonist
|
GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM). |
| PC-35465 |
PBI-4050 sodium
GPR40 agonist, GPR84 antagonist
|
PBI-4050 (Setogepram, Fezagepras) sodium is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
| PC-35464 |
PBI-4050
GPR40 agonist, GPR84 antagonist
|
PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
| PC-63157 |
AZ1729
FFA2 agonist
|
AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways. |
