Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ARN14494
Catalog No.: PC-35857Not For Human Use, Lab Use Only.
ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM; prevents the synthesis of pro-inflammatory cytokines TNFα and IL1β, growth factor TGFβ1, and oxidative stress-related enzymes iNOS and COX2 in mouse primary cortical astrocytes, also exerts neuroprotective properties in primary cortical neurons; inhibits the synthesis of long-chain ceramides and dihydroceramides that are involved in AD progression, promotes neuronal survival after astrocyte amyloid beta 1-42 injury.
| M.Wt | 424.545 | |
| Formula | C24H32N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. De Vita T, et al. ACS Chem Neurosci. 2018 Nov 27. doi: 10.1021/acschemneuro.8b00556.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
