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Chemical Structure : ARUK2007145
Catalog No.: PC-21274Not For Human Use, Lab Use Only.
ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.
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ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ.
ARUK2007145 shows good activity in the InCELL Pulse target engagement assay (PI5P4Kγ pIC50=7.3).
ARUK2007145 shows a good dual activity in the ADP-Glo assays showing similar activities for PI5P4Kγ+ and PI5P4Kα (fold-selectivity=5).
| M.Wt | 384.90 | |
| Formula | C18H13ClN4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gregory G Aldred, et al. RSC Med Chem. 2023 Aug 23;14(10):2035-2047.
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