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Chemical Structure : ARV-771
CAS No.: 1949837-12-0
Catalog No.: PC-42297Not For Human Use, Lab Use Only.
ARV-771 is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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ARV-771 is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM.
ARV-771 is equally potent activity in VCaP and LnCaP95 CRPC cell lines, causes depletion of c-MYC with IC50<1 nM.
ARV-771 suppresses both AR signaling and AR levels and leads to tumor regression in a CRPC mouse xenograft model.
| M.Wt | 986.6398 | |
| Formula | C49H60ClN9O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-c |
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1. Raina K, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.
2. Saenz DT, et al. Leukemia. 2017 Jan 31. doi: 10.1038/leu.2016.393.
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