Cat. No. |
Product Name |
Information |
PC-22120 |
ARV-393
BCL6 degrader
|
ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 62 nM in CAL148 cells. |
PC-21118 |
HDAC3 PROTAC P7
HDAC3 PROTAC
|
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%). |
PC-20920 |
SJ3149
CK1α degrader
|
SJ3149 (SJ-3149) is uniquely potent and selective CK1α degrader with DC50 of 3.7 nM and Dmax 95% in MOLM-13 cells, potently inhibits the viability of MOLM-13 cells with IC50 of 13 nM. |
PC-20886 |
JQAD1
EP300 degrader
|
JQAD1 is a potent, selective PROTAC degrader of p300, demonstrate a time-dependent loss of EP300, enhancer acetylation, and transcriptional output in NB cells both in vitro and in vivo. |
PC-20684 |
BSJ-04-146
FAK PROTAC
|
BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM. |
PC-20665 |
ARV-766
AR PROTAC
|
ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. |
PC-20560 |
NX-2127
BTK PROTAC
|
NX-2127 (NX2127) is a hetero-bifunctional, orally active PROTAC that induces the degradation of BTK and IKZF3 ubiquitination and proteasomal degradation in cells through recruitment of cereblon (CRBN). |
PC-20466 |
BSJ-05-037
ITK PROTAC
|
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. |
PC-20356 |
UNC8153
NSD2 degrader
|
UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark. |