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Cat. No. Product Name Information
PC-24632

MS9117

LSD1 PROTAC

MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader, effectively degrades LSD1 and demonstrates superior antiproliferative effects in AML cells.
PC-24472

KTX207

PDE4 PROTAC

KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively.
PC-24380

CDK2 degrader Cpd 1

CDK2 degrader

CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1.
PC-24182

KT-253

MDM2 degrader

Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer.
PC-23963

DEG-77

IKZF2/CK1α degarder

DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively.
PC-23962

CC-91633

CK1α degrader

CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α).
PC-23961

DEG-35

IKZF2/CK1α degarder

DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity.
PC-23910

QZ2135

RET PROTAC

QZ2135 is a potent, selective RET PROTAC degrader, effectively degrades RET kinase (DC50=4.7 nM) and its resistant mutants, such as V804M (DC50=17.2 nM) and G810C/R.
PC-23898

FTO PROTAC QP73

FTO degrader

FTO PROTAC QP73 is a first-in-class PROTAC degrader for the RNA demethylase FTO, efficiently induces FTO protein degradation in a dose-, time-, cereblon (CRBN)-, and proteasome-dependent manner in AML cells (DC50=34.9 nM, NB4 cells).
PC-23836

Gridegalutamide

AR degrader

Gridegalutamide (BMS-986409) is an orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity.
PC-23772

HLB-0532259

Aurora-A PROTAC

HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.
PC-23444

SD-436

STAT3 PROTAC

SD-436 is a highly potent and selective STAT3 PROTAC degrader with DC50 of 10 nM and Dmax >95% in SU-DHL-1 lymphoma cell line.

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