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Chemical Structure : ARV-825
CAS No.: 1818885-28-7
Catalog No.: PC-45097Not For Human Use, Lab Use Only.
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ARV-825 (ARV825) is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome.
ARV-825 shows more significant and longer lasting c-MYC suppression than small molecule inhibitors (JQ1, OTX015).
ARV-825 treatment leads to a superior effect on BL cells proliferation suppression.
| M.Wt | 923.4316 | |
| Formula | C46H47ClN8O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide |
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1. Lu J, et al. Chem Biol. 2015 Jun 18;22(6):755-63.
2. Abruzzese MP, et al. J Hematol Oncol. 2016 Dec 1;9(1):134.
3. Saenz DT, et al. Leukemia. 2017 Jan 31. doi: 10.1038/leu.2016.393.
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