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Chemical Structure : AS 2444697
Catalog No.: PC-60997Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.
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A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1; inhibited IL-1β- or TLR ligand lipopolysaccharide (LPS)-induced IL-6 production in human lung alveolar epithelial cells, fibroblast-like synoviocytes, and peripheral blood mononuclear cells; significantly reduces urinary protein excretion and preventd the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure in mice model of chronic kidney disease.
| M.Wt | 432.865 | |
| Formula | C19H21ClN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kondo M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19.
2. Imanishi J, et al. Arthritis Rheum 63:S390.
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