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AS 2553627

Chemical Structure : AS 2553627

CAS No.: 1251906-07-6

AS 2553627 (AS2553627;AS-2553627)

Catalog No.: PC-60988Not For Human Use, Lab Use Only.

AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively; displays no inhibitory activity against a panel of protein kinases, including SYK and ZAP70 at 1 uM; inhibits proliferation of IL-2 stimulated human and rat T cells with IC50 of 2.4 and 4.3 nM, respectively, inhibits the proliferation of TF-1 cells stimulated with EPO with IC50 of 12 nM; effectively prevents chronic rejection in rat cardiac allografts in rat cardiac transplant model alone or co-administration with tacrolimus.

    Physicochemical Properties

    M.Wt 321.384
    Formula C18H19N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-((3R,4R)-3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

    References

    1. Nakamura K, et al. Eur J Pharmacol. 2017 Feb 5;796:69-75.

    2. Nakamura K, et al. Transpl Immunol. 2017 Oct 5. pii: S0966-3274(17)30038-2.

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