| Cat. No. |
Product Name |
Information |
| PC-25681 |
OB756
JAK2 inhibitor
|
OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway. |
| PC-25191 |
Rovadicitinib
JAK/ROCK inhibitor
|
Rovadicitinib (TQ05105) is a potent, oral dual JAK1/2 and ROCK1/2 inhibitor targeting inflammatory and fibrotic components of chronic graft-versus-host disease (cGVHD). |
| PC-25062 |
ESK-001
TYK2 inhibitor
|
ESK-001 (Envudeucitinib) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2. |
| PC-22993 |
Pacritinib
JAK2/FLT3 inhibitor
|
Pacritinib (SB1518) is a potent, selective JAK2/FLT3 inhibitor with IC50 of 23 and 19 nM for JAK2(WT) and JAK2(V617F), and IC50 of 22 nM for FLT3. |
| PC-22617 |
Oclacitinib
JAK inhibitor
|
Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22495 |
MS-1020
JAK3 inhibitor
|
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner. |
| PC-22404 |
GLPG3667
TYK2 inhibitor
|
Cadefrecitinib (GLPG3667) is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM. |
| PC-22378 |
TYK2 inhibitor X
TYK2 inhibitor
|
TYK2 inhibitor X is a potent, selective and blood-brain barrier (BBB) permeable TYK2 inhibitor. |
| PC-22203 |
JAK3 inhibitor MJ04
JAK3 inhibitor
|
JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity. |
| PC-21734 |
ATI-1777
JAK1/3 inhibitor
|
ATI-1777 (Lepzacitinib) is a potent, selective and ATP-competitive JAK1/3 inhibitor with IC50 of 1.5/3.6/7.1/19.0 nM for JAK1/JAK2/JAK3/TYK2, respectively. |
| PC-21376 |
MMT3-72
JAK inhibitor
|
MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM). |
| PC-21236 |
ABBV-712
TYK2-JH2 inhibitor
|
ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2. |
