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AS2575959

Chemical Structure : AS2575959

CAS No.: 1616871-34-1

AS2575959 (AS 2575959;AS-2575959)

Catalog No.: PC-60999Not For Human Use, Lab Use Only.

AS2575959 is a novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AS2575959 is a novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo.
AS2575959 demonstrates a synergistic effect on insulin secretion and plasma GLP-1 level combined with DPP-IV inhibitor.

Physicochemical Properties

M.Wt 554.615
Formula C32H35NaO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Sodium [(3S)-6-({4'-[(3S)-3,4-dihydroxybutoxy]-2,2',6'-trimethyl[1,1'-biphenyl]-3-yl}methoxy)-3H-spiro[1-benzofuran-2,1'-cyclopropan]-3-yl]acetate

References

1. Tanaka H, et al. Life Sci. 2014 Jan 17;94(2):115-21.

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